2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141259
    C-NH-Boc-C-Bis-(C1-PEG1-PFP) 1807521-01-2
    C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    C-NH-Boc-C-Bis-(C1-PEG1-PFP)
  • HY-140544
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid 2086689-04-3
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
  • HY-138733
    Propargyl-PEG13-Boc
    Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG13-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG13-Boc
  • HY-140524
    N-(Azido-PEG2)-N-Boc-PEG3-acid 2086689-01-0
    N-(Azido-PEG2)-N-Boc-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG2)-N-Boc-PEG3-acid
  • HY-168276
    Boc-Nonanol 3036972-61-6
    Boc-Nonanol is a PROTAC linker. Boc-Nonanol can be used in the synthesis of PROTAC TRIB2 degrader-1 (HY-168274) .
    Boc-Nonanol
  • HY-130984
    Azido-PEG1-CH2COO-Cl 79598-49-5
    Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-CH2COO-Cl
  • HY-140229
    m-PEG36-amine
    m-PEG36-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG36-amine
  • HY-174222
    4-Piperidineethanol-piperidine-Boc 3056570-35-2
    4-Piperidineethanol-piperidine-Boc is a PROTAC linker can be used in the synthesis of PROTAC BRD4 Degrader-31 (HY-174210).
    4-Piperidineethanol-piperidine-Boc
  • HY-138459
    Propargyl-PEG9-THP
    Propargyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG9-THP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG9-THP
  • HY-140422
    t-Boc-Aminooxy-PEG3-alcohol 252378-66-8
    t-Boc-Aminooxy-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG3-alcohol
  • HY-134707
    CHO-PEG12-Boc
    CHO-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    CHO-PEG12-Boc
  • HY-141321
    PEG3-bis(phosphonic acid diethyl ester) 1807539-03-2
    PEG3-bis(phosphonic acid diethyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3-bis(phosphonic acid diethyl ester)
  • HY-140834
    Boc-N-Amido-PEG2-C2-azide 950683-55-3
    Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-N-Amido-PEG2-C2-azide
  • HY-140404
    Aminooxy-PEG3-methyl ester 2086689-03-2
    Aminooxy-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG3-methyl ester
  • HY-140172
    Boc-NH-PEG3-sulfonic acid 1817735-32-2
    Boc-NH-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG3-sulfonic acid
  • HY-140188
    Amino-PEG6-amido-C16-COOH
    Amino-PEG6-amido-C16-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG6-amido-C16-COOH
  • HY-140564
    N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester 2112732-03-1
    N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester
  • HY-138335
    Boc-PEG8-Boc 1432970-18-7
    Boc-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG8-Boc
  • HY-138759
    Thiol-PEG3-NHBoc 1895922-68-5
    Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3-NHBoc
  • HY-140805
    Azido-PEG20-alcohol 1637297-21-2
    Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG20-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG20-alcohol
PROTAC Linkers Isoform Comparison

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